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MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use. •  Over 50,000 bioactive molecules in stock •  Target 1,000+ key proteins in 20+ signaling pathways •  Quality reports (LC/MS, NMR...

  Cellular Senescence in Cornelia de Lange Syndrome : A Pharmacological Target? Tuesday, April 30, 2024 CEST 10:00 / IST 13:30 / JST & KST 17:00 Dr. Michel Pucéat • Research director at Inserm • Team leader and senior researcher In This Webinar, You Will Learn: • Programmed embryonic cell senescence in cardiac...

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Apoptosis is programmed cell death, and abnormal apoptosis can lead to the development of diseases such as cancer, neurological disorders and autoimmune diseases[1]. Two main apoptosis pathways: Intrinsic Pathway The intrinsic pathway, also known as the Bcl-2 regulatory or mitochondrial pathway (Figure 1), is regulated by Bcl-2 family proteins, including pro-apoptotic proteins (Bid, Bax, Bak) and anti-apoptotic...

Organoids are three-dimensional (3D) miniature structures cultured uing human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs). Compared with traditional 2D cell culture, organoids can closelymimic the cellular heterogeneity, structure, and function of the original organ and are widely used in drug development, precision...