An Immune-Based Memory Mechanism: The Memory Circuit "Created" by TLR9 Inflammatory Signals and DNA Damage! 1. "Brain Inflammation" and DNA Damage: The Surprising Keys to Long-Term Memory When you hear "inflammation" and "DNA damage," you might immediately think of disease or injury. However, in brains, these two...
Lipid Nanoparticles (LNPs) Lipid Nanoparticles (LNPs) are nanoscale drug delivery vectors, typically composed of four key components: ionizable lipids, cholesterol, PEGylated lipids, and structural lipids (auxiliary lipids). The type and composition ratio of lipids, along with other formulation parameters, determine critical structural and biological characteristics...
GMP Small Molecules Empower Cell Therapy: Reshaping the Future of Medicine In early January 2025, MIT Tech Review unveiled its annual list of top 10 breakthrough technologies poised to redefine the future. Among these, stem cell therapy stood out for its potential to treat diverse diseases—including...
Antibody drug conjugates (ADCs) are class of targeted therapies that combine precise targeting capabilities of monoclonal antibodies with the potent effects of cytotoxic payloads. Known for their ability to selectively identify and destroy cancer cells, ADCs represent a groundbreaking advancement in oncology. Figure 1. The...
Chronic kidney disease (CKD) poses a significant global health issue, leading to the progressive loss of kidney function. Renal fibrosis commonly accompanies CKD, characterized by excessive deposition of extracellular matrix (ECM). This process causes tissue remodeling and scarring in the renal parenchyma. Myofibroblasts drive renal fibrosis through...
Molecular interaction analyses have become invaluable tools in modern biomedical and life science research. They enable scientists to unravel the complex biological processes, identify potential drug candidates, understand drug-target binding kinetics, and accelerate with the discovery of novel therapeutics. At MedChemExpress (MCE), we offer a...
DNA-encoded Library (DEL) DNA-encoded library (DEL) is a technology where each small molecule compound is linked to a unique DNA sequence at the DNA level, enabling DNA encoding similar to assigning a "barcode" to each molecule. DEL screening is a technique used in the early...
Animal models that accurately mimic diseases can be generated through genetic engineering, spontaneous generation, and chemical induction. Ideally, a valuable animal model of any disease should have pathology similar to that of human disease[1]. Compared with genetic engineering and spontaneous models, chemically induced animal...
MedChemExpress (MCE) provides a wide range of life-science biochemicals, including more than 100,000 bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use. CAS No.: 55096-26-9 Nalmefene Research Area: Opioid Receptor/Neurological Disease • An orally active opioid antagonist, which acts as an antagonist at the μ-opioid...
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