19 Mar New Small Molecules from MCE for March 2020
MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use.
| • Over 15,000 bioactive molecules in stock • Target 375 key proteins in 20 signaling pathways • Quality reports (LC/MS, NMR and HPLC) for each product • Release more than 500 of the newest biochemicals per month |
• High purity & competitive prices • Data sheet with detailed biological information • Delivery within 24 hours |
| • Angiotensin Receptor Antagonist TD-0212 CAS No. : 1073549-11-7 TD-0212 (compound 35) is an orally active dual pharmacology angiotensin II type 1 receptor (AT1) antagonist and neprilysin (NEP) inhibitor, with a pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP. |
32 specific libraries for high throughput screening (HTS) and high content screening (HCS). Optimized for drug screening and new indication research. |
| • Vasopressin Receptor Antagonist SRX246 CAS No. : 512784-93-9 SRX246 is a potent, CNS-penetrant, highly selective, orally bioavailable vasopressin 1a (V1a) receptor antagonist (Ki=0.3 nM for human V1a). SRX246 has no interaction at V1b and V2 receptors. SRX246 also displays negligible binding at 64 others receptors classes, including 35 G-proteincoupled receptors. |
Cell Signaling Pathway
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| • DNA/RNA Synthesis Inhibitor Caracemide CAS No. : 81424-67-1 Caracemide (NSC-253272) inhibits the enzyme ribonucleotide reductase of Escherichia coli. Caracemide is a novel anticancer agent derived from a hydroxamic acid and has demonstrated to produce severe central nervous system (CNS) toxicity. |
• MAP3K Inhibitor TC ASK 10 CAS No. : 1005775-56-3 TC ASK 10 (Compound 10) is a potent, selective and orally active apoptosis signal-regulating kinase 1 (ASK1) inhibitor with an IC50 of 14 nM. The inhibitory activities of TC ASK 10 towards other representative panel of kinases are less than 50%, except for ASK2 (IC50 of 0.51 μM). |
| • MIF Inhibitor 4-IPP CAS No. : 41270-96-6 4-IPP (4-Iodo-6-phenylpyrimidine) is a specific suicide substrate and irreversible inhibitor of macrophage migration inhibitory factor (MIF). |
Compound Screening Libraries
Other New Products This Month