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MCE | NEW BIOACTIVE MOLECULES FOR MARCH 2023

07 Mar MCE | NEW BIOACTIVE MOLECULES FOR MARCH 2023

Posted at 02:19h in News by
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MCE (MedChemExpress) provides a wide range of lifescience biochemicals, including more than 40,000 bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use. If you need these products, please do not hesitate to contact us via mysales@bstmgroup.com.

  • Over 50,000 bioactive molecules in stock
  • Target 1,000+ key proteins in 20+ signaling pathways
  • Quality reports (LC/MS, NMR and HPLC) for each product
  • Release more than 1,000 newest biochemicals per month
  • Data sheet with detailed biological information
  • High purity & competitive prices
  • Delivery within 24 hours

CAS No.: 129830-38-2
Y-27632 dihydrochloride GMP
Research Area: ROCK Inhibitor/Cell Therapy

  • Y-27632 dihydrochloride was produced by using GMP guidelines.
  • An orally active and ATP-competitive ROCK inhibitor.
  • Induces fibroblasts to convert into pluripotent stem cells (hiPSCs).

CAS No.: 1630936-95-6
VU0422288
Research Area: mGluR Modulator

  • A group III mGlu receptor positive allosteric modulator with EC50 values of 108, 146, and 128 nM for mGluR4, mGluR7, and mGluR8, respectively.
  • Shows selectivity over a panel of 68 other GPCRs, ion channels and transporters.
  • Potentiates mGlu7-mediated reductions in excitatory post synaptic potentials.

Solubility: DMSO : 25 mg/mL (69.41 mM; Need ultrasonic)

CAS No.: 1425945-63-6
EHT 5372
Research Area: DYRK Inhibitor

  • A highly potent and selective inhibitor of DYRK’s family kinases.
  • Dose-dependently reduces pS396-Tau levels.
  • Reduces Aβ production in a dose-dependent reduction.

Solubility: DMSO : 6.67 mg/mL (16.50 mM; ultrasonic and warming and heat to 60°C)

CAS No.: 2763260-39-3
NRX-252114
Research Area: Molecular Glue

  • A potent enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP.
  • Further enhances the ubiquitylation of pSer33/S37A β-catenin peptide to form long ubiquitin chains.
  • Potentiates the ubiquitylation of unphosphorylated Ser33/S37A β-catenin peptides.

Solubility: DMSO : 100 mg/mL (195.96 mM; Need ultrasonic)

CAS No.: 1814881-70-3
LEM-14
Research Area: NSD2 Inhibitor

  • The first NSD2 specific inhibitor.
  • A hit inhibitor with an in vitro IC50 of 132 μM against H3K36 methylation by NSD2.

Solubility: DMSO : 50 mg/mL (104.48 mM; Need ultrasonic)

Animal venoms are complex mixtures with specific pathophysiological functions. The venoms usually consist of enzymes, proteins without enzymatic activity, and peptides. Such a wide range of peptides and proteins with diverse biological functions makes animal venoms rich sources of biologically active molecules for the development of new medicines. Several drugs based on the venom components have been successfully elaborated. For example, Eptifibatide, used to prevent heart attacks or the formation of blood clots, is an analogue of barbourin, a disintegrin isolated from Sistrurus miliarius barbouri snake venom. Otherwise, venoms are also used in basic research, diagnosis, as well as cosmetics.

MCE supplies more than 100 kinds of venoms, exacting from snakes, scorpions and spiders. These venoms can be used for screening active ingredients from venoms.

Snake Venoms
Scorpion Venoms
Spider Venoms

MCE PEI Transfection Reagent is designed based on 25 kDa PEI. It has high-efficiency, low-toxicity, strong-stability, and is suitable for many cell types, such as HEK-293、HEK-293T、CHO-K1、COS-1、COS-7、NIH/3T3、Sf9、

HepG2 and HeLa etc, even some hard-to-transfect cells. It can also be applied to large-scale recombinant protein expression and virus production.

Figure 1. The process of the PEI Transfection Reagent

MCE CTG Cell Viability Detection Reagent is used for detecting the number and viability of living cells in culture based on high-sensitivity bioluminescence detection technology of the ATP present.

Figure 2. The detection principle of CTG

Latest Publications Citing Use of MCE Products

Immunity.
2023 Feb 14;56(2):272-288.e7.
Cell.
2023 Feb 2;186(3):591-606.e23.
Cell.
2023 Jan 19;186(2):346-362.e17.
Cell.
2023 Jan 19;186(2):413-427.e17.

Cell Signaling Pathways

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