BioSynTech Malaysia Group Sdn Bhd | MCE | NEW SMALL MOLECULES FOR NOVEMBER 2021

06 Nov MCE | NEW SMALL MOLECULES FOR NOVEMBER 2021

Posted at 08:48h in News by Editorial BSTM

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MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use.

• Over 30,000 bioactive molecules in stock
• Target 500+ key proteins in 20+ signaling pathways
• Quality reports (LC/MS, NMR and HPLC) for each product
• Release more than 500 of the newest biochemicals per month
• Data sheet with detailed biological information
• High purity & competitive prices
• Delivery within 24 hours

TAS-117 hydrochloride
Research Area: Akt Inhibitor/Multiple Myeloma

• Potent, selective, orally active allosteric Akt inhibitor (IC50s of 4.8, 1.6, and 44 nM for Akt1, 2, and 3, respectively).
• Triggers anti-myeloma activities and enhances fatal endoplasmic reticulum (ER) stress induced by proteasome inhibition.
• Induces apoptosis and autophagy.

Solubility: DMSO : 62.5 mg/mL (135.59 mM; ultrasonic and warming and heat to 60°C)

CAS No.: 2230044-57-0
MB710
Research Area: p53 Mutation Y220C Stabilizer/Gastric Cancer

• An aminobenzothiazole derivative and a potent oncogenic p53 mutation Y220C stabilizer.
• Binds tightly to the Y220C pocket and stabilizes p53-Y220C.
• Shows anticancer activity in p53-Y220C cell lines.

Solubility: DMSO : 25 mg/mL (54.67 mM; Need ultrasonic)

CAS No.: 1069858-99-6
ML359
Research Area: Protein Disulfide Isomerase Inhibitor/Arterial Thrombosis-Related Diseases

• Specific inhibitor of protein disulfide isomerase (PDI) with an IC50 of 250 nM.
• Inhibits thrombus formation in a mouse laser injury model.

Solubility: DMSO : 100 mg/mL (239.27 mM; Need ultrasonic)

CAS No.: 736183-35-0
BGC-20-1531 free base
Research Area: Prostanoid EP4 Receptor Antagonist/Migraine Headache

• Potent and selective prostanoid EP4 receptor antagonist, exhibits high affinity at recombinant human EP4 receptors expressed in cell lines (pKB=7.6).
• Competitively antagonizes PGE2-induced vasodilatation of human middle cerebral (pKB=7.8) and meningeal (pKB=7.6) arteries.

Solubility: DMSO : 250 mg/mL (507.57 mM; Need ultrasonic)

CAS No.: 195199-95-2
SB 258719
Research Area: 5-HT7 Receptor Antagonist/Cancer and Neurological Disease

• Potent and selective 5-HT7 receptor antagonist with high affinity (pKi=7.5).
• Antagonizes surmountably 5-CT-stimulated adenylyl cyclase activity and reduces proliferation of HuH-7 and HepG2 cells, and also down regulates β-catenin.

Solubility: DMSO : 250 mg/mL (738.53 mM; Need ultrasonic)

CAS No.: 1636894-46-6
KA2507
Research Area: HDAC6 Inhibitor/Melanoma and Colorectal Cancer

• Potent and selective HDAC6 inhibitor, with an IC50 of 2.5 nM.
• Shows antitumor efficacy and immune modulatory effects in preclinical models.

Solubility: DMSO : 66.67 mg/mL (206.84 mM; Need ultrasonic)

SYBR Green qPCR Master Mix (Universal)

MCE SYBR Green qPCR Master Mix (Universal) is compatible with all qPCR instruments. 2× ready-to-use formulations which consist of antibody-mediated hot start polymerase, MgCl2, dNTPs and a proprietary reaction buffer, produce optimal results in qPCR experiments.

Comparison of chemical and antibody hot-start technologies

Anti-infection Related Libraries

COVID-19 continues to spread globally and imposes a heavy burden on society. Infections caused by pathogens such as viruses, bacteria, fungi, and parasites pose a serious threat to people's health. Furthermore, resistance to antimicrobial agents has become a major source of morbidity and mortality worldwide. So it is urgent to develop novel and effective anti-infection drugs. MCE provides a unique collection of 1800+ anti-infection compounds with confirmed anti-bacterial, anti-viral, anti-fungal, and anti-parasite activities that can be used for anti-infection drug screening and mechanism research.

Cat. No.	Anti-infection libraries	Number of compounds
HY-L002	Anti-infection Compound Library	1800+
HY-L027	Antiviral Compound Library	600+
HY-L049	Antibacterial Compound Library	800+
HY-L067	Antibiotics Library	500+
HY-L048	Antifungal Compound Library	200+
HY-L082	Antiparasitic Compound Library	300+
HY-L073	Anti-Hepatitis C Virus Compound Library	200+
HY-L052	Anti-COVID-19 Compound Library	1500+