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| MedChemExpress (MCE) provides an extensive collection of life-science biochemicals, including over 100,000 bioactive compounds, dye reagents, peptides and natural compounds for research applications. |
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CAS No.: 2980682-00-4
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Research Area: Polo-like Kinase (PLK)/Breast Cancer/Neuroblastoma
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A selective and orally active PLK4 inhibitor with an IC50 of 3 nM. |
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Disrupts centriole biogenesis in cancer cells, leading to the accumulation of PLK4 and p21 proteins. |
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Can be used in the research on breast cancer and neuroblastoma. |
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Solubility: DMSO: 100 mg/mL (194.34 mM; Need ultrasonic)
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CAS No.: 433953-86-7
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Research Area: Sirtuin/Cardiac Dysfunction
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A selective, orally active and allosteric SIRT3
(sirtuin 3) agonist with a Kd
value of 4.7 μM. |
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Induces protective autophagy/mitophagy and prevents
mitochondrial dysfunction. |
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Can be used in the research on cardiac
dysfunction. |
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Solubility: DMSO: 7.78 mg/mL (22.21 mM; Need ultrasonic)
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CAS No.: 2753651-10-2
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Research Area: PROTAC/Androgen Receptor/Prostate Cancer
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An orally bioavailable androgen receptor (AR)
PROTAC degrader with a DC50 of 2.7 nM. |
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Inhibits wild-type and mutant AR signaling. |
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Can be used in the research on prostate cancer. |
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Solubility: DMSO: 50 mg/mL (61.02 mM; Need ultrasonic)
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| MedChemExpress Compound Library |
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| Provides professional compound library, serving cancer, immunity, metabolism and other fields of research. |
| Product Name |
Description |
Neuropeptide Library |
Neuropeptides are small protein substances produced and released by
neurons through regulating secretory pathways. They are expressed in
neurons and function as neurotransmitter or co-neurotransmitter, acting as neural signaling substrates.
The library offers 110+ neuropeptides which can be applied to
mechanism research on central nervous system diseases. |
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| Latest Publications Citing Use of MCE Products |
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Nature.
2025 May;641(8065):1298-1308.
Nature.
2025 May;641(8065):1268-1275.
Nature.
2025 Apr;640(8060):1083-1092.
Nature.
2025 Apr;640(8058):514-523. |
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