 |
| MedChemExpress offers a wide range of high quality research chemicals and biochemicals including novel bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use. |
| • Over 100,000 bioactive molecules in stock |
| • Target 10,000+ key proteins in 20+ signaling pathways |
| • Quality reports (LC/MS, NMR and HPLC) for each product |
| • Release more than 1,000 latest biochemicals per month |
| • Data sheet with detailed biological information |
| • High purity & competitive prices |
| • Delivery within 24 hours |
|
|
CAS No.: 158876-82-5
|
|
|
|
|
Target/Research Area: Histamine Receptor/Inflammation
|
 |
| • |
A selective and orally active histamine H1 receptor and platelet activating factor (PAF) antagonist. |
| • |
Binds to histamine H1 receptor and PAF with Ki values of 0.55 μM and 0.1 μM, respectively. |
| • |
Can be used for the research of allergic rhinitis and urticaria. |
|
|
|
Solubility: DMSO: 125 mg/mL (300.51 mM; Need ultrasonic)
|
|
|
CAS No.: 2308520-97-8
|
|
|
|
|
Target/Research Area: JAK/Inflammation
|
 |
| • |
A reversible, ATP-competitive and orally active TYK2 inhibitor with an IC50 of 2.3 nM. |
| • |
Selectively inhibits IFNα-induced STAT1 phosphorylation in human PBMC and whole blood assays. |
| • |
Can be used for the research of inflammatory and autoimmune diseases. |
|
|
|
Solubility: DMSO: 50 mg/mL (112.75 mM; Need ultrasonic)
|
|
|
CAS No.: 112885-41-3
|
|
|
|
|
Target/Research Area: nAChR/Neurological Disease
|
 |
| • |
A selective α9 nAChR agonist with an EC50 of 230 nM. |
| • |
Inhibits ATP-induced IL-1β release in THP-1 cells. |
| • |
Attenuates inflammatory pain in mice in an α7 nAChR-independent manner. |
|
|
|
Solubility: DMSO: 100 mg/mL (214.43 mM; Need ultrasonic)
|
|
| MedChemExpress Natural Products |
|
|
|
| Alkaloids are naturally occurring nitrogen-containing alkaline compounds. They account for about 20% of the total secondary metabolites of plants, participate in regulating important growth processes of plants, and play an important role in drug development and the defense response of organisms. |
| Product Name |
Description |
| Monocrotaline |
11-Membered macrocyclic pyrrolizidine alkaloid; OCT-1/OCT-2 inhibitor |
| Pilocarpine |
M3 muscarinic receptor agonist; used for research of primary glaucoma and dry mouth |
| Bicuculline |
Competing GABAA receptor antagonist; anticonvulsant; induces epileptic seizure in mice |
| Vinblastine Sulfate |
Mitotic inhibitor; apoptosis inducer; NF-κB inhibitor |
|
|
|
| MedChemExpress Isotope-labeled Compounds |
|
|
|
|
|
|
Latest Publications Citing Use of MCE Products |
 |
Nature.
2025 Feb;638(8050):519-527.
Cell.
2025 Feb 6;188(3):814-831.e21.
Cell.
2025 Feb 6;188(3):814-831.e21.
Cell.
2025 Feb 6;188(3):653-670.e24. |
|
 |
