| Molecular interaction analyses have become invaluable tools in modern biomedical and life science research. They enable scientists to unravel the complex biological processes, identify potential drug candidates, understand drug-target binding kinetics, and accelerate with the discovery of novel therapeutics. |
| At MedChemExpress (MCE), we offer a comprehensive suite of cutting-edge molecular interaction detection technologies to support your research requirements. Here’s a glimpse of our advanced services: |
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MedChemExpress (MCE) Services: |
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| Methods |
Features |
Applications |
| Surface Plasmon Resonance (SPR) |
Data*: KD, Ka, Kd |
• Proteins
• Small molecules
• Peptides
• Nucleic acids
• Liposomes
• Lipids
• Polysaccharides
• Cells
• Cell lysates
• and more |
| Advantages: High sensitivity, real-time kinetics, label-free, versatility |
| Microscale Thermophoresis (MST) |
Data: KD |
| Advantages: Preferred for weak affinity, detection is not limited by buffer |
| Isothermal Titration Calorimetry (ITC) |
Data: KD, stoichiometric ratio (n), entropy change (△H), enthalpy change (△S) |
| Advantages: Simulate reactions under physiological conditions and measure thermodynamic data |
| Bio-Layer Interferometry (BLI) |
Data: KD, Ka, Kd |
| Advantages: Simple operation, high-throughput detection possible |
| nano-Differential Scanning Fluorimetry (nanoDSF) |
Data: Melting temperature (Tm) |
| Advantages: Detection under natural conditions, study of protein stability |
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| * KD: affinity constant, Ka: association rate constant, Kd: dissociation rate constant |
| SPR-the “gold standard” for molecular interaction detection |
| Surface Plasmon Resonance (SPR) is a highly sensitive, label-free biosensing technology that provides real-time binding kinetics and affinity data by monitoring the interactions of biomolecules on metal film surfaces. |
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| Figure 1. Schematic diagram of SPR principle (concept image from MCE). |
| At MCE, we are committed to offering a comprehensive suite of drug screening services with our one-stop platform. We have experienced experts and cutting-edge facilities for Surface Plasmon Resonance (SPR), Microscale Thermophoresis (MST), Isothermal Titration Calorimetry (ITC), Bio-Layer Interferometry (BLI) and nano-Differential Scanning Fluorimetry (nanoDSF). Whether you’re exploring protein stability, evaluating drug-target interactions, or screening potential drug candidates, MCE’s advanced technologies and expertise are here to support your research goals. |
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| Figure 2. Schematic diagram of molecular interaction analysis technologies (concept image from MCE). SPR; MST; BLI; ITC; nanoDSF. |
MCE Advantages |
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