15 May NEW BIOACTIVE MOLECULES FOR MAY 2023
MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use.
• Over 50,000 bioactive molecules in stock
• Target 1,000+ key proteins in 20+ signaling pathways
• Quality reports (LC/MS, NMR and HPLC) for each product
• Release more than 1,000 latest biochemicals per month
• Data sheet with detailed biological information
• High purity & competitive prices
• Delivery within 24 hours
CAS No.: 1354030-52-6
UNC9995
Research Area: Dopamine Receptor/Depression
- Aβ-arrestin2-biased agonist of dopamine receptor Drd2.
- Inhibits NLRP3 inflammasome activation by enhancing β-arrestin2-NLRP3 interaction, thus prevents neuronal degeneration.
- Improves depressive behavior in mouse models, and improves astrocytes dysfunctions.
Solubility: DMSO: 50 mg/mL (118.38 mM; ultrasonic and warming and heat to 60°C)
CAS No.: 1202193-89-2
ThioLox
Research Area: Lipoxygenase/Inflammation/Immunology
- A competitive 15-lipoxygenase-1 (15-LOX-1) inhibitor.
- Shows anti-inflammatory and neuroprotective properties.
- Prevents lipid peroxidation and mitochondrial superoxide formation in neuronal cells.
Solubility: DMSO : 100 mg/mL (364.46 mM; ultrasonic and warming and heat to 60°C)
CAS No.: 2361988-77-2
cRIPGBM chloride
Research Area: Apoptosis/Cancer
- An orally active, proapoptotic derivative.
- Targets to RIPK2 to induce caspase 1-dependent apoptosis.
- Exerts potent anti-tumor activity in vivo animal models.
Solubility: DMSO: 25 mg/mL (55.94 mM; ultrasonic and warming and heat to 60°C)
CAS No.: 639858-32-5
BMS-605541
Research Area: VEGFR/Cancer
- A selective and orally active inhibitor of VEGFR-2 kinase.
- Inhibits the activity of Flk-1, VEGFR-1 and PDGFR-β with IC50 values of 40 nM, 400 nM and 200 nM, respectively.
Solubility: DMSO: 33.33 mg/mL (83.03 mM; ultrasonic and warming and heat to 60°C)
CAS No.: 12386731-32-9
UNC0321
Research Area: Histone Methyltransferase/Cancer
- A potent and selective histone methyltransferase G9a inhibitor with a Ki value of 63 pM.
- Inhibits high glucose-induced apoptosis in HUVEC by targeting Rab4.
Solubility: DMSO: 50 mg/mL (104.48 mM; Need ultrasonic)
MCE New Compound Libraries in April
| Cat. No. | Product Name | Description |
|---|---|---|
| HY-L151 | PROTAC Library | PROTACs (PROteolysis-TArgeting Chimeras) is a class of molecules that utilize ubiquitin-proteasome system (UPS) to ubiquitinate and degrade target proteins. The PROTACs molecule consists of two ligands joined by a linker. The one-to-one interaction between PROTACs and target proteins determines the high efficiency of PROTACs, making it a potential molecule for targeted protein degradation (TPD) therapy. MCE supplies a unique collection of 60 PROTACs that effectively degrade target proteins with more powerful screening capability. MCE PROTAC Library is a useful tool for signal pathway research, protein degradation therapy research, drug discovery and drug repurposing, etc. |
| HY-L152 | F-Fragments Library | 19F-NMR has proved to be a detection mode in fragment-based drug discovery (FBDD) for studies of protein structure and interactions. 19F shows high sensitivity for NMR detection, and the exquisite sensitivity of 19F to ligand binding makes it a valuable approach in FBDD.F (Fluorine) -Fragments can be used for 19F-NMR detection after binding to target proteins, and can be used as an effective 19F-NMR tool for FBDD. MCE designs a powerful collection of 4,600+ F-fragments, all of which obey a heuristic rule called the "Rule of Three (RO3)". This F-fragments library is an important source of lead-like drugs. |
MCE Recombinant Proteins
MCE provides a variety of recombinant proteins for the generation of organoid and 2D cell culture, including animal-free recombinant proteins and GMP-grade recombinant proteins.
| Cat. No. | Product Name | Application |
|---|---|---|
| HY-P70453B | Wnt3a Surrogate, Human | Recombinant proteins for organoid culture |
| HY-P700143AF | Animal-Free Noggin, Human | Recombinant proteins for organoid culture, Animal-free recombinant proteins |
| HY-P700051AF | Animal-Free EGF, Human | Recombinant proteins for organoid culture, Animal-free recombinant proteins |
| HY-P700090AF | Animal-Free FGF-4, Human | Recombinant proteins for organoid culture, Animal-free recombinant proteins |
| HY-P70440G | GMP FGF basic/bFGF, Human | Recombinant proteins for organoid culture, GMP-grade recombinant proteins |
| HY-P70558G | GMP Noggin, Human | Recombinant proteins for organoid culture, GMP-grade recombinant proteins |
Latest Publications Citing Use of MCE Products
Nature.
2023 April 14;616(7957):563-573.
Nature.
2023 April 2;616(7956):348-356.
Cell.
2023 March 30;186(7):1352-1368.e18.
Immunity.
2023 March 14;56(3):500-515.e6.
Cell Signaling Pathways
