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MCE | New Bioactive Molecules for July 2022

05 Jul MCE | New Bioactive Molecules for July 2022

Posted at 07:55h in News by
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MCE (MedChemExpress) provides a wide range of lifescience biochemicals, including more than 30,000 bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use.
• Over 30,000 bioactive molecules in stock

• Target 500+ key proteins in 20+ signaling pathways
• Quality reports (LC/MS, NMR and HPLC) for each product
• Release more than 500 newest biochemicals per month
• Data sheet with detailed biological information
• High purity & competitive prices

If you need these products, please do not hesitate to contact us via mysales@bstmgroup.com.

CAS No.: 943609-66-3
Vedolizumab (anti-α4β7-integrin)
Research Area: Integrin/Inflammatory Bowel Diseases (IBD)

• A competitive antagonist of HOX/PBX interaction.
• Prevents HOX/PBX dimers from binding to DNA.
• Selectively inhibits cell proliferation and promotes apoptosis in cancer cells.

HXR9 hydrochloride
Research Area: HOX/PBX/Leukemia

• A humanized IgG1 monoclonal antibody that targets the α4β7 integrin selectively.
• Restricts the recruitment of β7+ effector monocytes to the intestinal epithelium.

Solubility: H2O : 50 mg/mL (18.15 mM; Need ultrasonic)

CAS No.: 1582289-91-5
ACT001
Research Area: PAI-1/Glioma

• An orally active, BBB-penetrant PAI-1 inhibitor by inhibiting the phosphorylation of PI3K and AKT.
• Possesses potent anti-glioblastoma (GBM) activity and immunomodulatory effects.
• Significantly decreases PD-L1 expression in a dose-dependent manner.

Solubility: DMSO : 100 mg/mL (244.22 mM; ultrasonic and warming and heat to 60°C)
H2O : 100 mg/mL (244.22 mM; Need ultrasonic

CAS No.: 2251806-70-7
Pirepemat fumarate
Research Area: Parkinson’s Disease

• A corticalpreferring catecholamine- and cognition-promoting agent.
• Has no significant effect on acute hyper-dopaminergic or hypo-glutamatergic motor responses, but reverses deficits resulting from hypomonoaminergic function.

Solubility: DMSO : 100 mg/mL (303.67 mM; Need ultrasonic)

PROTAC-O4I2
Research Area: PROTAC/Intestinal Tumor

• Highly potent and selective degrader of splicing factor 3B1 (SF3B1).
• Induces FLAG-SF3B1 degradation with an IC50 value of 0.244 μM in K562 cells.
• PROTAC-O4I2 also induces cellular apoptosis in K562 WT cells.

Solubility: DMSO : 250 mg/mL (410.44 mM; Need ultrasonic)

MCE Peptide Library/MCE Cyclic Peptide Library
Library Description
MCE Peptide Library
600+ peptides, including bioactive peptides, amino acid derivatives, and blocking peptides;
MCE Peptide Library can be used for peptide library screening, peptide drug discovery, vaccine development, target verification, structural activity research, etc.
MCE Cyclic Peptide Library 50+ cyclic peptides, such as Gramicidin, Cyclosporine A, Vancomycin, etc;
With the features of good binding affinity, target selectivity and low toxicity;
MCE Cyclic Peptide Library is a powerful tool for drug discovery and PPI inhibitor screening.

MCE Exosomes-related Kits

Exosomes are small vesicles (30-150 nm) containing RNA and protein that are secreted by various types of cells in culture, and found in abundance in body fluids including blood, saliva, urine, and breast milk. Exosomes are thought to function as intercellular messengers, delivering their cargo of effector or signaling macromolecules between specific cells.

MCE provides a simple and effective method to isolate and purify intact exosomes from cell culture media and plasma/serum. Combined with Exosome Protein Detection Kit (CD63&TSG101), it is suitable to detect the isolated exosomes.

Cat. No. Product Size Application
HY-K1062
Exosome Isolation and Purification Kit (from cell culture media)
 20T Isolation of exosome
HY-K1063
Exosome Isolation and Purification Kit
(from plasma and serum)
 30T Isolation of exosome
HY-K1064 Exosome Protein Detection Kit
(CD63 & TSG101)		 5T
Isolation of exosome

Recent Publications Citing Use of MCE Products

Nature. 2022 May;605(7910):567-574.
Nature. 2022 May;605(7911):747-753.
Cell. 2022 May 11;S0092-8674(22)00526-8.
Adv Mater. 2022 May;34(21):e2200517.

Cell Signaling Pathways

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