24 Jan MCE | NEW SMALL MOLECULES FOR JANUARY 2022
Kinase Screening Service
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Kinases are critical in metabolism, cell signalling, protein regulation, cellular transport, secretory processes and many other cellular pathways, which makes them key regulators of cell function. The malfunction of kinases causes a variety of human diseases. Therefore, kinases represent a class of attractive drug targets. However, the highly conserved structure of eukaryotic kinases (especially the catalytic domain) has brought great challenges to the development of highly selective kinase inhibitors. Broad profiling, for many, has become a requirement of new kinase inhibitor programs for better understanding structure/activity relationships. MCE can provide high-quality and comprehensive kinase assay panel. High-quality data on the binding affinity/activity difference between compounds and kinases can evaluate the target selectivity of compounds.
<!– SYBR Green qPCR Master Mix (Universal) –>
Kinases are critical in metabolism, cell signalling, protein regulation, cellular transport, secretory processes and many other cellular pathways, which makes them key regulators of cell function. The malfunction of kinases causes a variety of human diseases. Therefore, kinases represent a class of attractive drug targets. However, the highly conserved structure of eukaryotic kinases (especially the catalytic domain) has brought great challenges to the development of highly selective kinase inhibitors. Broad profiling, for many, has become a requirement of new kinase inhibitor programs for better understanding structure/activity relationships. MCE can provide high-quality and comprehensive kinase assay panel. High-quality data on the binding affinity/activity difference between compounds and kinases can evaluate the target selectivity of compounds.
Key Features:
• A long list of kinases: 400+ kinases, including AGC, CAMK, CMGC, CK1, STE, TK, TKL and common mutants.
• Flexible and customizable kinase panel: Characteristic TK, CDK kinase profiles, 60/207/302 kinase panels and customized kinase panels.
• Various detection: TR-FRET (LANCE Ultra, LathaScreen, HTRF), fluorescence method (Kinase-Glo, ADP-Glo), Z`-LYTE, binding assay.
• Accurate detection, rapid data.
• Flexible and customizable kinase panel: Characteristic TK, CDK kinase profiles, 60/207/302 kinase panels and customized kinase panels.
• Various detection: TR-FRET (LANCE Ultra, LathaScreen, HTRF), fluorescence method (Kinase-Glo, ADP-Glo), Z`-LYTE, binding assay.
• Accurate detection, rapid data.
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