OX40 Agonism & Immunotherapy
OX40, also known as gp34, CD134, or TNFRSF4, is a member of the TNF superfamily. It is primarily expressed on activated effector and regulatory CD4 and CD8 T cells and can also be expressed by NKT cells, NK cells, and neutrophils in the immune system. New pre-clinical and clinical trials indicate that OX40 agonism is effective in combination therapies for cancer and overcoming resistance to immunotherapy.
