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New Small Molecules from MCE for January 2021

New Small Molecules from MCE for January 2021

MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use.

• Over 25,000 bioactive molecules in stock
• Target 375 key proteins in 20+ signaling pathways
• Quality reports (LC/MS, NMR and HPLC) for each product
• Release more than 500 of the newest biochemicals per month
• High purity & competitive prices
• Data sheet with detailed biological information
• Delivery within 24 hours
• Cardiomyogenic Agent
VUT-MK142            CAS No. : 1313491-22-3VUT-MK142 is a potent new cardiomyogenic synthetic agent promoting the differentiation of pre-cardiac mesoderm into cardiomyocytes, which may be useful to differentiate stem cells into cardiomyocytes for cardiac repair.

Compound Screening Libraries

 

 

50 specific libraries for high throughput screening (HTS) and high content screening (HCS). Optimized for drug screening and new indication research.

• CAV1 Oligomers Disrupter
WL47WL47, a high-affinity cavolin-1 (CAV1) ligand (Kd=23 nM), is a potent disrupter of CAV1 oligomers. WL47 shows selectivity for CAV1 over BSA, casein and HEWL. WL47 is 80% smaller in length than the original T20 (HY-P0052) parent sequence and can be used for the study of caveolin-1 function.

Cell Signaling Pathway

• Sodium Channel Agonist
TPC2-A1-PTPC2-A1-P is a powerful and membrane permeable agonist of two pore channel 2 (TPC2) with an EC50 of 10.5 μM. TPC2-A1-P plays its role by mimicking the physiological actions of PI(3,5)P2. TPC2-A1-P also shows higher potency to induce Na2+ mobilisation from TPC2 than TPC-A1-N (HY-131614). TPC2-A1-P can be used to probe different functions of TPC2 channels in intact cells.
• Recent Publication Citing used MCE

1. Nature. 2020 Dec;588(7836):169-173.
2. Cell. 2020 Dec 1;S0092-8674(20)31445-8.
3. Cell. 2020 Dec 15;S0092-8674(20)31615-9.
4. Nat Methods. 2020 Dec 7.
DOI: 10.1038/s41592-020-01011-4.
5. Immunity. 2020 Nov 25;
S1074-7613(20)30468-4.

• Lipoxygenase Inhibitor
4-MMPB                                                          CAS No. : 928853-86-5

4-MMPB is a selective inhibitor of 15-lipoxygenase, with an IC50 of 18 μM. 4-MMPB has IC50s of 19.5 μM and 19.1 μM for soybean 15-lipoxygenase (SLO) and human 15-lipoxygenase-1 (15-LOX-1), respectively. 4-MMPB has potential for the research of prostate cancer.

• c-Met/HGFR Inhibitorr
SYN1143                                   CAS No. : 913376-84-8SYN1143 is a potent, selective and orally active dual inhibitor of c-Met/RON, with IC50s of 4 and 9 nM, respectively. SYN1143 has weak inhibitory activity on LckTie2Src, and BTK with IC50s ranging from 160 to 710 nM. SYN1143 can be used for the research of cancers that RON and c-Met are activated.

 

Other New Products This Month

G5-7 (JAK) TML-6 (Amyloid-β) GR 125743 (5-HT Receptor)
APG-1387 (IAP) COH-SR4 (AMPK) Practolol (Adrenergic Receptor)
URB937 (FAAH) L-006235 (Cathepsin) Compstatin TFA (Complement System)
Tolebrutinib (BTK) CBS1117 (Influenza Virus) …