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BioSynTech Malaysia Group Sdn Bhd
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Level 17, Top Glove Tower,
No. 16, Persiaran Setia Dagang,
Setia Alam, Seksyen U13,
40170 Shah Alam, Selangor Darul Ehsan, Malaysia.

 

T : +6 03 8025 1603
F : +6 03 8025 1637
E : info@bstmgroup.com

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New Small Molecules from MCE for December 2020

New Small Molecules from MCE for December 2020

MCE (MedChemExpress) provides a wide range of lifescience biochemicals, including more than 25,000 bioactive compounds, recombinant proteins, dye reagents, peptides and natural compounds for laboratory and scientific use.

 

• GOT1 Inhibitor
iGOT1-01t             CAS No. : 882256-55-5GOT1-01 is a potent aspartate aminotransferase 1 (glutamate oxaloacetate transaminase 1; GOT1) inhibitor. iGOT1-01 has IC50s of 85 μM and 11.3 μM in MDH coupled GOT1 enzymatic assay and GOT1/GLOX/HRP assay, respectively. iGOT1-01 has anti-cancer activity.

Compound Screening Libraries

 

 

50 specific libraries for high throughput screening (HTS) and high content screening (HCS). Optimized for drug screening and new indication research.

• FPR2 Agonist
BMS-986235                          CAS No. : 2253947-47-4Disitertide (P144) TFA is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block the interaction with its receptor. Disitertide (P144) TFA is also a PI3K inhibitor and an apoptosis inducer.

Cell Signaling Pathway

• RET Inhibitor
WF-47-JS03WF-47-JS03 is a potent and selective RET kinase inhibitor with IC50s of 1.7 nM and 5.3 nM for KIF5B-RET transfected Ba/F3 cells and CCDC6-RET transfected LC-2/ad lung cancer cells, respectively. WF-47-JS03 demonstrates >500-fold selectivity against kinase insert domain receptor (KDR). Effective brain penetration.
• Recent Publication Citing used MCE

NNature. 2020 Oct 21.
doi: 10.1038/s41586-020-2844-1.
Nature. 2020 Nov 18.
doi: 10.1038/s41586-020-2925-1.

• GABA Receptor Activator
COR659 COR659 is a potent and effective GABAB positive allosteric modulator (PAM). COR659 suppresses alcohol and chocolate self-administration in rats..
• SOD3 Activator
BNTA                                     CAS No. : 685119-25-9BNTA, a potent extracellular matrix (ECM) modulator, facilitates cartilage structural molecule synthesis on chondrocytes by activating superoxide dismutase 3 (SOD3). BNTA shows a promising potential for osteoarthritis alleviation by modulating cartilage generation.

 

Other New Products This Month

 

IQ-3 (JNK)
Aviptadil
(SARS-CoV)

GRP-60367 hydrochloride
(RABV)
FB23 (FTO) SP-96 (Aurora Kinase)
FSL-1 TFA
(Toll-like Receptor (TLR))
BD750 (JAK) CP-547632 TFA (VEGFR) PZ-128 (Protease-Activated Receptor (PAR))
RSVA405 (AMPK) S-23 (Androgen Receptor) …