Contact Us

BioSynTech Malaysia Group Sdn Bhd
Revongen Corporation Center,
Level 17, Top Glove Tower,
No. 16, Persiaran Setia Dagang,
Setia Alam, Seksyen U13,
40170 Shah Alam, Selangor Darul Ehsan, Malaysia.

 

T : +6 03 8025 1603
F : +6 03 8025 1637
E : info@bstmgroup.com

Social Media

New Small Molecules from MCE for November 2020

New Small Molecules from MCE for November 2020

MCE (MedChemExpress) provides a wide range of lifescience biochemicals, including more than 25,000 bioactive compounds, recombinant proteins, dye reagents, peptides and natural compounds for laboratory and scientific use.

• Over 25,000 bioactive molecules in stock
• Target 375 key proteins in 20+ signaling pathways
• Quality reports (LC/MS, NMR and HPLC) for each product
• Release more than 500 of the newest biochemicals per month
• High purity & competitive prices
• Data sheet with detailed biological information
• Delivery within 24 hours
• Estrogen Receptor/ERR Antagonist
Giredestrant            CAS No. : 1953133-47-5

Giredestrant (GDC-9545), a non-steroidal estrogen receptor (ER) ligand, is an orally active and selective ER antagonist. Giredestrant potently competes with Estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor activity.

Compound Screening Libraries

 

 

50 specific libraries for high throughput screening (HTS) and high content screening (HCS). Optimized for drug screening and new indication research.

• TGF-beta/Smad Inhibitor
Disitertide TFA

Disitertide (P144) TFA is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block the interaction with its receptor. Disitertide (P144) TFA is also a PI3K inhibitor and an apoptosis inducer.

Cell Signaling Pathway

• PKC Inhibitor
Delcasertib hydrochloride       CAS No. : 143797-62-0

Delcasertib (KAI-9803) hydrochloride is a potent and selective δ-protein kinase C (δPKC) inhibitor. Delcasertib (KAI-9803) hydrochloride could ameliorate injury associated with ischemia and reperfusion in animal models of acute myocardial infarction (MI).

• Recent Publication Citing used MCE

Nature. 2020 Oct;586(7829):407-411. (IF: 42.778).

• Phosphodiesterase (PDE) Inhibitor
BRD9500

BRD9500 is an orally active phosphodiesterases 3 (PDE3) inhibitor with IC50s of 10 and 27 nM for PDE3A and PDE3B, respectively. Antitumor activity.

• PI3K Inhibitor
MSC2360844                   CAS No. : 1305267-37-1

MSC2360844 is a potent, orally active and selective PI3Kδ inhibitor, with an IC50 of 145 nM. MSC2360844 shows highly selective against a panel of 278 additional kinases.

 

Other New Products This Month

ML406 (Bacterial) SB 243213 (5-HT Receptor) Plecanatide (Guanylate Cyclase)
Diloxanide (Parasite) VAF347 (Aryl Hydrocarbon Receptor) GSK046 (Epigenetic Reader Domain)
KL001 (Cryptochrome) Ganaplacide hydrochloride (Parasite) GSK356278 (Phosphodiesterase (PDE))
Jatrorrhizine (Alkaloids) …