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BioSynTech Malaysia Group Sdn Bhd
Revongen Corporation Center,
Level 17, Top Glove Tower,
No. 16, Persiaran Setia Dagang,
Setia Alam, Seksyen U13,
40170 Shah Alam, Selangor Darul Ehsan, Malaysia.

 

T : +6 03 8025 1603
F : +6 03 8025 1637
E : info@bstmgroup.com

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NEW SMALL MOLECULES FROM MCE FOR AUGUST 2020

NEW SMALL MOLECULES FROM MCE FOR AUGUST 2020

MCE (MedChemExpress) provides a wide range of lifescience biochemicals, including more than 25,000 bioactive compounds, recombinant proteins, dye reagents, peptides and natural compounds for laboratory and scientific use.

• IRAK Inhibitor
JH-X-119-01 hydrochloride

JH-X-119-01 hydrochloride is a potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 hydrochloride ameliorates LPS-induced sepsis in mice.

Compound Screening Libraries

 

 

70 specific libraries for high throughput screening (HTS) and high content screening (HCS). Optimized for drug screening and new indication research.

• Complement System
ML417                                   CAS No. : 1386162-69-1

EG01377 dihydrochloride is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1), with a Kd of 1.32 μM, and IC50s of 609 nM for both NRP1-a1 and NRP1-b1. EG01377 dihydrochloride has antiangiogenic, antimigratory, and antitumor effects.

Cell Signaling Pathway

• Histone Methyltransferase Inhibitor
OTS186935 hydrochloride

OTS186935 hydrochloride is a potent protein methyltransferase SUV39H2 inhibitor with an IC50 of 6.49 nM. OTS186935 hydrochloride shows significant inhibition of tumor growth in mouse xenograft models without any detectable toxicity. OTS193320 hydrochloride regulates the production of γ-H2AX in cancer cells.

• Recent Publication Citing used MCE

1. Nature. 2020 Jul;583(7817):620-624. doi:
10.1038/s41586-020-2502-7.

• KLF Inhibitor
SR18662

SR18662 is a potent inhibitor of Krüppel-like factor five (KLF5) with an IC50 of 4.4 nM and an analogue of ML264 (HY-19994) with improved inhibitory potency against colorectal cancer cells. SR18662 can be used for the study of colorectal cancer.

• Histone Acetyltransferase Inhibitor
TH1834          CAS No. : 2108830-08-4

TH1834 is a specific Tip60 (KAT5) histone acetyltransferase (HAT) inhibitor. TH1834 induces apoptosis and increases DNA damage in breast cancer. TH1834 does not affect the activity of related histone acetyltransferase MOF. Anticancer activity.

 

Other New Products This Month

ASP4132 (AMPK) Urolithin C (Calcium Channel) Azvudine (Reverse Transcriptase)
DIMBOA (Bacterial) SCR7 pyrazine (CRISPR/Cas9) Prexasertib (Checkpoint Kinase (Chk))
Brilacidin (Bacterial) SB-277011 (Dopamine Receptor) Bleomycin hydrochloride (DNA/RNA Synthesis)
Cyclo(-RGDfK) (Integrin) …