08 May New Small Molecules from MCE for May 2020
MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use.
|• Over 25,000 bioactive molecules in stock
• Target 375 key proteins in 20+ signaling pathways
• Quality reports (LC/MS, NMR and HPLC) for each product
• Release more than 500 of the newest biochemicals per month
|• High purity & competitive prices
• Data sheet with detailed biological information
• Delivery within 24 hours
|• HIV Inhibitor
BRD-K98645985 CAS No. : 1357647-78-9
BRD-K98645985 is a BAF (mammalian SWI/SNF) transcriptional repression inhibitor with an EC50 of ~2.37 µM. BRD-K98645985 binds ARID1A-specific BAF complexes, prevents nucleosomal positioning, and potently reverses HIV-1latency, without T cell activation or toxicity.
Compound Screening Libraries
32 specific libraries for high throughput screening (HTS) and high content screening (HCS). Optimized for drug screening and new indication research.
|• DNA/RNA Synthesis Inhibitor
GS-443902 CAS No. : 1355149-45-9GS-443902
(GS-441524 triphosphate) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 1.1 µM, 5 µM for RSV RdRp and HCV RdRp, respectively. GS-443902 is the active triphosphate metabolite of Remdesivir.
Cell Signaling Pathway
|• CDK Inhibitor
YKL-5-124 TFA is a potent, selective, irreversible and covalent CDK7 inhibitor with IC50s of 53.5 nM and 9.7 nM for CDK7 and CDK7/Mat1/CycH, respectively. YKL-5-124 TFA is >100-fold greater selective for CDK7 than CDK9 and CDK2, and inactive against CDK12 and CDK13. YKL-5-124 TFA induces a strong cell-cycle arrest, inhibits E2F-driven gene expression, and exhibits little effect on RNA polymerase II phosphorylation status.
|• Recent Publication Citing used MCE
1. Nature. 2020 Apr;580(7803):386-390.
|• Caspase Inhibitor
Z-WEHD-FMK CAS No. : 210345-00-9
Z-WEHD-FMK is a potent, cell-permeable and irreversible caspase-1/5 inhibitor. Z-WEHD-FMK also exhibits a robust inhibitory effect on cathepsin B activity (IC50=6 μM). Z-WEHD-FMK can be used to investigate cells for evidence of apoptosis.
|• 5-LOX/COX Inhibitor
FPL 62064 CAS No. : 103141-09-9
FPL 62064 is a potent 5-lipoxygenase (5-LOX) and COX dual inhibitor, with IC50 values of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase (cyclooxygenase), respectively. FPL 62064 has potent anti-inflammatory activity.
Other New Products This Month
|EB-3D (AMPK)||TCID (Deubiquitinase)||Rotigaptide (Gap Junction Protein)|
|VBIT-12 (VDAC)||GW274150 (NO Synthase)||CPTH2 (Histone Acetyltransferase)|
|BYK204165 (PARP)||AZD7325 (GABA Receptor)||CM10 (Aldehyde Dehydrogenase (ALDH))|
|Neticonazole (Fungal) …|
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