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BioSynTech Malaysia Group Sdn Bhd
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No. 16, Persiaran Setia Dagang,
Setia Alam, Seksyen U13,
40170 Shah Alam, Selangor Darul Ehsan, Malaysia.


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New Small Molecules from MCE for May 2020

New Small Molecules from MCE for May 2020

MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use.

• Over 25,000 bioactive molecules in stock
• Target 375 key proteins in 20+ signaling pathways
• Quality reports (LC/MS, NMR and HPLC) for each product
• Release more than 500 of the newest biochemicals per month
• High purity & competitive prices
• Data sheet with detailed biological information
• Delivery within 24 hours


• HIV Inhibitor
BRD-K98645985                  CAS No. : 1357647-78-9

BRD-K98645985 is a BAF (mammalian SWI/SNF) transcriptional repression inhibitor with an EC50 of ~2.37 µM. BRD-K98645985 binds ARID1A-specific BAF complexes, prevents nucleosomal positioning, and potently reverses HIV-1latency, without T cell activation or toxicity.

Compound Screening Libraries



32 specific libraries for high throughput screening (HTS) and high content screening (HCS). Optimized for drug screening and new indication research.

• DNA/RNA Synthesis Inhibitor
GS-443902               CAS No. : 1355149-45-9GS-443902

(GS-441524 triphosphate) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 1.1 µM, 5 µM for RSV RdRp and HCV RdRp, respectively. GS-443902 is the active triphosphate metabolite of Remdesivir.

Cell Signaling Pathway

• CDK Inhibitor
YKL-5-124 TFA

YKL-5-124 TFA is a potent, selective, irreversible and covalent CDK7 inhibitor with IC50s of 53.5 nM and 9.7 nM for CDK7 and CDK7/Mat1/CycH, respectively. YKL-5-124 TFA is >100-fold greater selective for CDK7 than CDK9 and CDK2, and inactive against CDK12 and CDK13. YKL-5-124 TFA induces a strong cell-cycle arrest, inhibits E2F-driven gene expression, and exhibits little effect on RNA polymerase II phosphorylation status.

• Recent Publication Citing used MCE

1. Nature. 2020 Apr;580(7803):386-390.
2. Nature. 2020 Mar;579(7799):433-437.
3. Science. 2020 Feb 14;367(6479):806-810.
4. Cell. 2020 Apr 6. pii: S0092-8674(20)30268-3.
5. Cell. 2020 Mar 5;180(5):941-955.e20.

• Caspase Inhibitor
Z-WEHD-FMK                     CAS No. : 210345-00-9

Z-WEHD-FMK is a potent, cell-permeable and irreversible caspase-1/5 inhibitor. Z-WEHD-FMK also exhibits a robust inhibitory effect on cathepsin B activity (IC50=6 μM). Z-WEHD-FMK can be used to investigate cells for evidence of apoptosis.

• 5-LOX/COX Inhibitor
FPL 62064          CAS No. : 103141-09-9

FPL 62064 is a potent 5-lipoxygenase (5-LOX) and COX dual inhibitor, with IC50 values of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase (cyclooxygenase), respectively. FPL 62064 has potent anti-inflammatory activity.


Other New Products This Month

EB-3D (AMPK) TCID (Deubiquitinase) Rotigaptide (Gap Junction Protein)
VBIT-12 (VDAC) GW274150 (NO Synthase) CPTH2 (Histone Acetyltransferase)
BYK204165 (PARP) AZD7325 (GABA Receptor) CM10 (Aldehyde Dehydrogenase (ALDH))
Neticonazole (Fungal) …