19 Mar New Small Molecules from MCE for March 2020
MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use.
|• Over 15,000 bioactive molecules in stock
• Target 375 key proteins in 20 signaling pathways
• Quality reports (LC/MS, NMR and HPLC) for each product
• Release more than 500 of the newest biochemicals per month
|• High purity & competitive prices
• Data sheet with detailed biological information
• Delivery within 24 hours
|• Angiotensin Receptor Antagonist
TD-0212 CAS No. : 1073549-11-7
TD-0212 (compound 35) is an orally active dual pharmacology angiotensin II type 1 receptor (AT1) antagonist and neprilysin (NEP) inhibitor, with a pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP.
Compound Screening Libraries
32 specific libraries for high throughput screening (HTS) and high content screening (HCS). Optimized for drug screening and new indication research.
|• Vasopressin Receptor Antagonist
SRX246 CAS No. : 512784-93-9
SRX246 is a potent, CNS-penetrant, highly selective, orally bioavailable vasopressin 1a (V1a) receptor antagonist (Ki=0.3 nM for human V1a). SRX246 has no interaction at V1b and V2 receptors. SRX246 also displays negligible binding at 64 others receptors classes, including 35 G-proteincoupled receptors.
Cell Signaling Pathway
|• DNA/RNA Synthesis Inhibitor
Caracemide CAS No. : 81424-67-1
Caracemide (NSC-253272) inhibits the enzyme ribonucleotide reductase of Escherichia coli. Caracemide is a novel anticancer agent derived from a hydroxamic acid and has demonstrated to produce severe central nervous system (CNS) toxicity.
|• MAP3K Inhibitor
TC ASK 10 CAS No. : 1005775-56-3
TC ASK 10 (Compound 10) is a potent, selective and orally active apoptosis signal-regulating kinase 1 (ASK1) inhibitor with an IC50 of 14 nM. The inhibitory activities of TC ASK 10 towards other representative panel of kinases are less than 50%, except for ASK2 (IC50 of 0.51 μM).
|• MIF Inhibitor
4-IPP CAS No. : 41270-96-6
4-IPP (4-Iodo-6-phenylpyrimidine) is a specific suicide substrate and irreversible inhibitor of macrophage migration inhibitory factor (MIF).
Other New Products This Month