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BioSynTech Malaysia Group Sdn Bhd
Revongen Corporation Center
No 12A, Jalan TP5,
Taman Perindustrian UEP,
47600 Subang Jaya, Selangor DE ,
Malaysia.

 

T : +6 03 8025 1603
F : +6 03 8025 1637
E : info@bstmgroup.com

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New Small Molecules from MCE for March 2020

New Small Molecules from MCE for March 2020

MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use.

• Over 15,000 bioactive molecules in stock
• Target 375 key proteins in 20 signaling pathways
• Quality reports (LC/MS, NMR and HPLC) for each product
• Release more than 500 of the newest biochemicals per month
• High purity & competitive prices
• Data sheet with detailed biological information
• Delivery within 24 hours

 

• Angiotensin Receptor Antagonist
TD-0212                       CAS No. : 1073549-11-7
TD-0212 (compound 35) is an orally active dual pharmacology angiotensin II type 1 receptor (AT1) antagonist and neprilysin (NEP) inhibitor, with a pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP.

Compound Screening Libraries

 

 

32 specific libraries for high throughput screening (HTS) and high content screening (HCS). Optimized for drug screening and new indication research.

• Vasopressin Receptor Antagonist
SRX246               CAS No. : 512784-93-9
SRX246 is a potent, CNS-penetrant, highly selective, orally bioavailable vasopressin 1a (V1a) receptor antagonist (Ki=0.3 nM for human V1a). SRX246 has no interaction at V1b and V2 receptors. SRX246 also displays negligible binding at 64 others receptors classes, including 35 G-proteincoupled receptors.

Cell Signaling Pathway

• DNA/RNA Synthesis Inhibitor
Caracemide             CAS No. : 81424-67-1
Caracemide (NSC-253272) inhibits the enzyme ribonucleotide reductase of Escherichia coli. Caracemide is a novel anticancer agent derived from a hydroxamic acid and has demonstrated to produce severe central nervous system (CNS) toxicity.
• MAP3K Inhibitor
TC ASK 10          CAS No. : 1005775-56-3
TC ASK 10 (Compound 10) is a potent, selective and orally active apoptosis signal-regulating kinase 1 (ASK1) inhibitor with an IC50 of 14 nM. The inhibitory activities of TC ASK 10 towards other representative panel of kinases are less than 50%, except for ASK2 (IC50 of 0.51 μM).
• MIF Inhibitor
4-IPP                     CAS No. : 41270-96-6
4-IPP (4-Iodo-6-phenylpyrimidine) is a specific suicide substrate and irreversible inhibitor of macrophage migration inhibitory factor (MIF).

 

Other New Products This Month

CINPA1 (CAR) FG 7142 (GABA Receptor) Arotinolol (Adrenergic Receptor)
Rosoxacin (Bacterial) HET0016 (Cytochrome P450) Fatostatin (Fatty Acid Synthase (FAS))
CKI-7 (Casein Kinase) PF-04995274 (5-HT Receptor) Deserpidine (Angiotensin-converting Enzyme (ACE))
KY-226 (Phosphatase) …