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New Small Molecules from MCE for January 2020

New Small Molecules from MCE for January 2020

MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use.

• Over 15,000 bioactive molecules in stock
• Target 375 key proteins in 20 signaling pathways
• Quality reports (LC/MS, NMR and HPLC) for each product
• Release more than 500 of the newest biochemicals per month
• High purity & competitive prices
• Data sheet with detailed biological information
• Delivery within 24 hours


• MAPKAPK2 (MK2) Inhibitor
PF-3644022                                    CAS No.: 1276121-88-0PF-3644022 is a potent, selective, orally active and ATP-competitive MAPKAPK2 (MK2) inhibitor with an IC50 of 5.2 nM and a Ki of 3 nM. PF-3644022 also inhibits MK3 and p38 regulated/activated kinase (PRAK) with IC50s of 53 nM and 5.0 nM, respectively. PF-3644022 potently inhibits TNFα production and has anti-inflammatory effect.

Compound Screening Libraries



32 specific libraries for high throughput screening (HTS) and high content screening (HCS). Optimized for drug screening and new indication research.

• Protease-Activated Receptor (PAR) Antagonist
SCH79797                        CAS No. : 1216720-69-2SCH79797 dihydrochloride is a highly potent, selective nonpeptide protease activated receptor 1 (PAR1) antagonist with an IC50 of 70 nM

Cell Signaling Pathway

• NO Synthase Inhibitor
                     CAS No. : 1781934-50-6

AR-C102222 hydrochloride is a potent, competitive, orally active and highly selective inducible nitric oxide synthase (iNOS) inhibitor, with an IC50 of 37 nM. AR-C102222 hydrochloride has antinociception and anti-inflammatory activity.

• CCR Antagonist
C-021                       CAS No. : 1784252-84-1

C-021 dihydrochloride is a potent CC chemokine receptor-4 (CCR4) antagonist. C-021 dihydrochloride potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM, respectively.

• Motilin Receptor Antagonist
MA-2029 MA-2029 is a selective, orally active, and competitive motilin receptor antagonist (IC50=4.9 nM).


Other New Products This Month

CY 208-243 (Dopamine Receptor) NS5806(Potassium Channel) FPA-124 (Akt)
PF-06882961 (Glucagon Receptor) NTP42 (Prostaglandin Receptor) Mifobate(PPAR)
PF-00356231 hydrochloride (MMP) GR 103691 (Dopamine Receptor) Prinomastat(MMP)
CYM 9484 (Neuropeptide Y Receptor)