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New Small Molecules from MCE for November 2019

New Small Molecules from MCE for November 2019

MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use.

• Over 15,000 bioactive molecules in stock
• Target 375 key proteins in 20 signaling pathways
• Quality reports (LC/MS, NMR and HPLC) for each product
• Release more than 500 of the newest biochemicals per month
• High purity & competitive prices
• Data sheet with detailed biological information
• Delivery within 24 hours


• BCRP Inhibitor
ML753286                                            CAS No.: 1699720-89-2ML753286 is an orally active and selective BCRP (Breast cancer resistance protein) inhibitor with an IC50 of 0.6 μM. ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions, and is stable in plasma cross species

Compound Screening Libraries



32 specific libraries for high throughput screening (HTS) and high content screening (HCS). Optimized for drug screening and new indication research.

• T Cell Costimulation Modulator
Abatacept                        CAS No. : 332348-12-6Abatacept (CTLA4lg) is a soluble fusion protein consisting of the extra-cellular domain of human CTLA4 and a fragment of the Fc portion of human IgG1 (hinge and CH2 and 3 domains). Abatacept is a selective T-cell co-stimulation modulator and a protein drug for the treatment of autoimmune diseases.

Cell Signaling Pathway

• CCR Antagonist
BMS CCR2 22                     CAS No. : 445479-97-0

BMS CCR2 22 is a potent, specific and high affinity CC-type chemokine receptor 2 (CCR2) antagonist with excellent binding affinity (binding IC50 of 5.1 nM) and potent functional antagonism (calcium flux IC50 of 18 nM and chemotaxis IC50 of 1 nM).

• Complement System Inhibitor
Danicopan                       CAS No. : 1903768-17-1

Danicopan (ACH-4471), a selective and orally active small-molecule factor D inhibitor, shows high binding affinity to human Factor D with Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits alternative pathway of complement (APC) activity, has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS).

• Melanocortin Receptor Antagonist
SNT-207858                      CAS No. : 1104662-66-9SNT207858 is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT207858 has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor.


Other New Products This Month

DHPG (mGluR) MMAF (Microtubule/Tubulin) TVB-3166 (Fatty Acid Synthase (FAS))
MJN110 (MAGL) Tipepidine (Potassium Channel) Tazemetostat (Histone Methyltransferase)
Epertinib (EGFR) BI-167107 (Adrenergic Receptor) KDOAM-25 citrate (Histone Demethylase)
INO-1001 (PARP) …